this study investigated the effect of enteral nutrition supplementation on glucose and lipid metabolism in non-insulin dependent diabetes mellitus(NIDDM) PATIENTS(N=29). Nutrition formula(400kcal/day) were supplied daily for eight weeks as a
substitute
for a snack or a meal. Subjects were divided into three groups based on changes of fasting blood glucose(FBG), glucose response area(GRA) on oral glucose tolerance test(OGTT). Before and after intake of nutrition formula : group 1 (the group of a
decrease in FBG and GRA, n=20), group 2(the group of a decrease in FBG and an increase in GRA, n=4), and group 3(the group of an increase in FBG and GRA, n=5). Before nutrition supplementation, group 3 showed a longer tendency of DM duration and
a
lower
tendency of insulin and C-peptide response area than those of group 1 and 2. At 8 weeks after nutrition supplementation, group 1 showed a significant increase in insulin and C-peptide response areas but group 2 and 3 showed no change in those
areas.
After nutrition supplementation, all three groups showed a tendency of decrease in glycated hemoglobin and no significant changes in the levels of serum triglycerides, HDL, LDL, totalcholcsterol, albumin, transferrin, creatinine. GOT and GPT. The
results suggest that using an enteral nutrition formula in NIDDM patients is a good substitute for a meal or a snack and could improve blood glucose control without any changes in lipid levels, and liver and kidney functions. The beneficial
effect
of
nutrition supplementation on glycemic control resulted from components of nutrition formula had such as additional fiber and high monounsaturated fatty acid as the source of fat to be helpful tp glycemic control in diabetics.
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